In a HNSCC heterotopic xenograft tumor model, treatment with the epidermal growth factor receptor (EGFR) blocker Cetuximab inhibits angiogenesis by downregulating Notch1 and Hypoxia-inducible factor 1 alpha (Hif1α) subunit [83]. This evidence concerns the gene NOTCH1 and head and neck squamous cell carcinoma.