The combination of PCDHGB6, HOXA9, MGMT and miR-126 showed an 85.2% sensitivity and 81.5% specificity in NSCLC diagnoses, indicating that the early diagnosis of NSCLC is feasible through the monitoring of promoter methylation using an effective combination of related genes [23]. The gene discussed is MGMT; the disease is non-small cell lung carcinoma.