Among the seven FTD genes analyzed, we observed only one pathogenic variant in the microtubule-associated protein tau gene (MAPT, c.1537 C>G, p.P513A), which was discovered in a male patient (#2) who developed progressive slowing in memory with an onset age of 51 years, while no pathogenic mutation was found in APP, PSEN1, or PSEN2 genes. This evidence concerns the gene PSEN2 and frontotemporal dementia.