Patients with biallelic and, in some instances, monoallelic mutations of the CYP24A1 gene have elevated serum calcium concentrations associated with elevated serum 1,25(OH)2D, suppressed parathyroid hormone (PTH) concentrations, hypercalciuria, nephrocalcinosis, nephrolithiasis, and on occasion, reduced bone density [5]. Here, CYP24A1 is linked to Hypercalciuria.