The compounds responsible for the above mentioned effects appear to be the flavonoids named fisetin and butein, since fisetin increases the intracellular levels of glutathione and inhibits the activity of cyclooxygenase-2 (COX-2) and type II nitric oxide synthase (iNOS), which makes it an excellent therapeutic candidate for diminishing the progression of Alzheimer’s disease and other neurodegenerative diseases. Here, PTGS2 is linked to neurodegenerative disease.