Importantly, treatment with a known Pgp1 inhibitor, cyclosporine A and standard dose corticosteroid, prednisolone (1 μM) resulted in synergistic inhibition of both IFNγ and TNFα production by steroid resistant NKT-like and NK cells from COPD patients [23] (Figure 3). The gene discussed is IFNG; the disease is chronic obstructive pulmonary disease.