The direct inhibition of α-glucosidase-dependent production of glucose before its passage across the intestinal barrier, the inhibition of insulin-stimulated glucose entry into fat cells, and the inhibition of glucose incorporation into neo-synthesized lipids are therefore mechanisms likely contributing to the resveratrol anti-obesity benefits, alongside many other actions [5]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.