We therefore primed T cells from patients with RRMS and healthy controls with a polyclonal stimulus (anti-CD3/CD28 beads) for 6 days and thereafter re-stimulated the cells for 20 min with either 100 ng/mL IL-6, IL-12, IL-23, or medium alone to induce phosphorylation of STAT3 and STAT4. The gene discussed is CD28; the disease is relapsing-remitting multiple sclerosis.