In correlation with the consideration that TNF-β as an inflammatory cytokine is a key decisive factor in cancer promotion, we showed that resveratrol, like anti-TNF-βR with TNF-β co-treatment, significantly decreased cell migration and EMT of CRC cells and promoted biochemical changes to MET with a planar cell surface and suppressed formation of CSC, and this was accompanied by a marked increase in apoptosis. The gene discussed is TNFRSF1B; the disease is colorectal carcinoma.