SNAI2 and neoplasm: In addition, these data are in accordance with findings from other studies, indicating that tumor cells change their morphology and phenotype from epithelial to higher cell motility and malignancy-mesenchymal phenotypes, and synthetize EMT-specific factors during tumorigenesis [23], accompanied by down-modulation of cell adhesion molecules (E-cadherin) and stimulation of vimentin, slug, and matrix metalloproteinase expression [55].