These results suggest that the flavonoid metabolite 2,4,6-THBA may mediate its anti-cancer effects through a CDK- and SLC5A8-dependent pathway, whereas, 3,4-DHBA and 3,4,5-THBA are likely to exert their effect through a CDK- and SLC5A8-independent pathway. The gene discussed is SLC5A8; the disease is cancer.