Furthermore, APELA expression was expressed in all the molecular subtypes of GBM, with somewhat higher APELA expression observed in both the proneural and mesenchymal subtypes (Figure 6B) Taken together, the close relationship of APELA expression with brain tumor patient survival and tumor grade at diagnosis suggests that APELA plays an important role in glioma pathogenesis. The gene discussed is APELA; the disease is brain neoplasm.