Furthermore, recent experimental research has indicated that in FABP4 knockout mice (KO) with obesity induced by a high-fat diet, cartilage degradation is significantly alleviated after 6 months of daily oral gavage with a selective FABP4 inhibitor has suggested that FABP4 may be a potential therapeutic target in OA [106]. The gene discussed is FABP4; the disease is obesity due to melanocortin 4 receptor deficiency.