Moreover, adiponectin can mediate changes in effector cells in RA disease pathophysiology, inducing gene expression and protein synthesis in human RA synovial fibroblasts (RASFs), lymphocytes, endothelial cells and chondrocytes [29], enhancing prostaglandin E2 production in RASFs via AdipoR1 [30,31]. The gene discussed is ADIPOR1; the disease is rheumatoid arthritis.