Indeed, resistin has been found to specifically enhance the concentrations of chemokines CXCL8 and CCL2, as well as IL-6, in RA FLSs; transfecting the FLSs with adenylate cyclase-associated protein 1 (CAP1, a receptor for resistin) significantly reduced CXCL8 expression, which implicates the involvement of the resistin-CAP1 pathway in chemokine production in RA synovial tissue [67]. This evidence concerns the gene CAP1 and rheumatoid arthritis.