The median SIRT-3, p-mTOR and nuclear HIF-1α expression levels (percent of immunopositive tumor cells) were 35 (IQR 10–60), 0 (IQR 0–0) and 1 (IQR 0–10) in early-stage patients vs. 60 (IQR 10–90), 0 (IQR 0–0) and 0 (IQR 0–7.5) in advanced-stage patients, respectively. Here, MTOR is linked to neoplasm.