Patients with HIF-1α tumor expression <1% showed a five-year percent DFS of 20 months (95% CI 80-44) and an eight-year percent OS of 0 months (95% CI), compared with a five-year percent DFS of 100 months (95% CI) and an eight-year percent OS of 50 months (95% CI 0-100) for patients with HIF-1α tumor expression ≥1% (p = 0.002; p = 0.041, respectively) (Table 2 and Figure 4). This evidence concerns the gene HIF1A and neoplasm.