We observed a higher expression of SIRT-3 in patients with diabetes (median value of 60%) than non-diabetic patients (median value of 30%) (p = 0.011) (Figure 2B), and in patients treated with metformin than those taking insulin (70% vs. 30%, respectively) (p = 0.030), as shown in Figure 2C. The gene discussed is INS; the disease is diabetes mellitus.