Gd-IgA1 containing immune deposits and mesangial cell proliferation are characteristic features of IgAN[11].Significantly higher levels of circulating IgA1 with galactose-deficient, O-linked, hinge-region glycans have been reported in IgA nephropathy patients compared to non-IgA renal disease and healthy controls in Caucasians, African Americans, Japanese and Chinese populations [12–17]. This evidence concerns the gene IGHA1 and IgA glomerulonephritis.