Three of these genes are closely linked to regulating cell motility and metastasis, and as such were investigated further: HCF2 has been shown to regulate cellular filamentous-actin formation and to promote cell migration [25], BASP1 binds to the actin cytoskeleton and regulates cell motility [26, 27] and MALAT1 is a non-coding transcript associated with metastasis in lung adenocarcinoma [28]. This evidence concerns the gene SERPIND1 and lung adenocarcinoma.