The first set relates to genes that have been implicated in genistein’s regulation of prostate cell motility and metastasis and included MEK4, MMP-2 and BASP1. MEK4 was evaluated because it has been shown to drive human PCa metastasis [9], and is the pharmacologic target for genistein-mediated decreases in MMP-2 and inhibition of human PCa cell invasion [2]. The gene discussed is BASP1; the disease is posterior cortical atrophy.