Interestingly, the increase of Treg (and activated Treg) frequencies in HIV+ treatment-naïve individuals correlated negatively with the CD4/CD8 ratio (Fig 1C), perhaps in an attempt to reestablish the T-cell homeostasis lost during HIV infection (CD4+ T-cell depletion (Table 1) and CD8+ T-cell expansion (data not shown). This evidence concerns the gene CD4 and HIV infectious disease.