Interestingly, CASP5 mutations are associated with cancers (Offman et al., 2005), while CASP1 and CASP4 mutations are not (Soung et al., 2008), suggesting a caspase‐5‐specific protective role against tumorigenesis that is in keeping with SASP‐driven senescence surveillance. This evidence concerns the gene CASP4 and cancer.