2017; Escoll et al. 2017) (Fig. 3). The effects of mycobacterial proteins and the interaction of Mtb with the mitochondrial network remain largely unexplored. Recently, the host Immune-Responsive Gene 1 (Irg1; also called Acod1), a mitochondrial enzyme induced under inflammatory conditions that produces the metabolite itaconate, has been shown to be regulated Mtb. By using Irg1−/−and Irg1fl/fl conditional gene-deleted mice this study showed that complete absence of Irg1 during Mtb infection resulted in severe pulmonary disease and ultimately death (Nair et al. 2018). The gene discussed is ACOD1; the disease is lung disorder.