ARCI is a genetically heterogeneous condition that can be caused by pathogenic variants in at least 12 genes including TGM1 (OMIM #190195), ABCA12 (OMIM #607800), NIPAL4 (OMIM #609383), CYP4F22 (OMIM #611495), ALOX12B (OMIM #603741), ALOXE3 (OMIM #607206), LIPN (OMIM #613924), PNPLA1 (OMIM #612121), CERS3 (OMIM #615276), SDR9C7 (OMIM #609769), SULT2B1 (OMIM #604125), and CASP14 (OMIM #605848) (Fischer, 2009; Grall et al., 2012; Heinz et al., 2017; Kirchmeier, Zimmer, Bouadjar, Rösler, & Fischer, 2017; Lefèvre et al., 2003, 2006; Radner et al., 2013; Shigehara et al., 2016). The gene discussed is ABCA12; the disease is autosomal recessive congenital ichthyosis.