Among these, two common polymorphisms in the promoter, G to Asubstitution at position -238 (TNF-α-238G/A, rs361525) and position-308 (TNF-α-308G/A, rs1800629), attracted widespread attention.Several case-control studies were conducted to investigate the association ofTNF-α-238G/A and -308G/A with RA and SLE.However, significant associations with these two polymorphisms related to RA and SLEwere not consistently observed. This evidence concerns the gene TNF and systemic lupus erythematosus.