Potential effect modification of the association of CBS promoter methylation with hypertension and stroke by age, gender, BMI, Hcy, drinking and smoking history were examined in subgroups analyses, while significant effect modification was observed by gender in patients with hypertension (p-values for interaction<0.001) and gender in patients with stroke (p-value for interaction=0.035, Table 3). Here, CBS is linked to hypertensive disorder.