MMP2 and intervertebral disk degenerative disorder: Though we identified aberrantly expressed key gene (MMP2) from the GEO database and found the AGE-RAGE signaling pathway and estrogen signaling pathway in degenerative disc AF cells for IDD, which may benefit us in understanding the molecular mechanism of the pathogenesis of IDD and detecting potential prognostic and diagnostic biomarkers, it is still needed that we perform further molecular biological experiments to confirm our assumptions.