TPO and familial thyroid dyshormonogenesis: Even though c.2145C>T (or p.Pro715Pro) of the four mutations is a synonymous point mutation and is innocuous, the other three nonsynonymous mutations, namely, p.Ala373Ser, p.Ser398Thr, and p.Thr725Pro, had previously been reported in the patients with thyroid dyshormonogenesis and the reaction kinetics catalyzed by the mutant TPO enzyme proved to be similar with nonenzymatic reaction rates by several other studies [20, 52, 53].