CASP8 and gastric cancer: In GC cells, dysregulated expression of the B-cell lymphoma 2 (Bcl-2) family, including Bcl-2, Bcl-xl, and Bad, and inhibitor of apoptosis proteins (IAPs), represented as X-linked inhibitor of apoptosis protein (XIAP), livin, and survivin, followed by inactivation of the caspase-3 or caspase-8 pathway, are the main causes of apoptosis resistance induced by chemotherapeutic drugs [9–11].