While cabozantinib blocks MET and VEGFR-2, it also has inhibitory activity against multiple other targets, such as RET, KIT, AXL, and TIE-2, providing additional rationale for combination therapy with erlotinib following resistance in the setting of osimertinib as front line therapy for EGFR mutant NSCLC. This evidence concerns the gene RET and non-small cell lung carcinoma.