The role of EMT in PCa metastasis has been studied (16) revealing significant interplay between EMT-related genes and tissue invasion on one hand, and alterations in TGF-β (17), IL-6 (18–20), AR variants (21, 22), FGF (23), and Wnt/β-catenin signaling pathways (24–26) on the other hand. This evidence concerns the gene AR and posterior cortical atrophy.