CDKN1A and skin neoplasm: Other reports have shown that EGCG increases the expression of p16(INK4A) p21(CIP1) in skin cancer cells by downregulation of HDAC activity and increasing the H3K9ac, H3K14ac, H4K5ac, H4K12ac, and H4K16ac levels (Nandakumar et al., 2011).