Among these are alanyl-tRNA synthetase (AARS), which is implicated in Charcot-Marie-Tooth disease (Latour et al., 2010); cadherin 2 (CDH2), which is involved in neuronal differentiation (Cherry et al., 2014); cysteine rich motor neuron 1 (CRIM1); neurexin (NRXN1); synuclein alpha (SNCA), which is a major component of amyloid plaques in patients with Alzheimers disease (Uéda et al., 1993; Matsubara et al., 2001; Lutz et al., 2015); and SRY-box 11 (SOX11), which plays a role in neural differentiation and the response to injury (Jankowski et al., 2006, 2009). This evidence concerns the gene AARS1 and early-onset autosomal dominant Alzheimer disease.