Using the more sensitive DEXSeq approach, 30 genes were determined to have differentially expressed CSIs (FDR < 0.05), including ATP binding cassette subfamily A member 1 (ABCA1), which is a candidate biomarker gene for Alzheimer's disease (Alonso Vilatela et al., 2012; Love et al., 2015). Here, ABCA1 is linked to early-onset autosomal dominant Alzheimer disease.