In systemic lupus, patients in the Ro52+Ro60+ group were more likely to have cytopenias (p = 0.04) and hypergammaglobulinemia (p = 0.01), whereas patients in the Ro52+Ro60- group were more at risk for renal insufficiency (p = 0.04) and needed more lines of treatment than patients in the other groups (p = 0.02). This evidence concerns the gene TRIM21 and Renal insufficiency.