To determine if increased expression of CXCR3 on CD4+ T cells during malaria was reflected in their ability to migrate in vitro to C-X-C chemokines, CD4+ T cells were purified from the spleens of naïve and infected B6 mice on day 8 p.i. and migration to CXCL9 and CXCL10 was assessed using Transwell plates as previously described (19). This evidence concerns the gene CD4 and malaria.