Recent analysis of the RA synovial citrullinome showed wide-spread protein citrullination within RA synovial fluid, and identified a number of citrullinated proteins that correspond with our dataset, such as actin (beta and gamma), cathepsin G, coronin, gelsolin, histone H1.3, histone H3.3, MNDA, MPO, myosin 9, and vimentin (110). This evidence concerns the gene H1-3 and rheumatoid arthritis.