Auto-antibodies that recognize catalase (97), lamin B1 and B2 (98–101), apolipoprotein A1 (102), annexin AI and α-enolase (103–105) have also been described in SLE, with annexin AI and α-enolase auto-antibodies being associated with skin and kidney involvement (104, 105). The gene discussed is CAT; the disease is systemic lupus erythematosus.