• MDSCs are present in lungs (3) but their role in development and evolution of granuloma remains unclear• Arg-1 is associated to severe TB in mouse models (104, 105) and is detected in necrotizing granulomas in humans (106). Pathway documented in MPs, however, deciphering neutrophil contribution to Arg-1 production would be of interest. This evidence concerns the gene ARG1 and Granuloma.