CSF2 and obesity due to melanocortin 4 receptor deficiency: ILC1s are mainly involved in the early protection against virus (6) and bacteria (7, 8) through the secretion of interferon-gamma (IFN-γ) and granulocyte-macrophage colony-stimulating factor (GM-CSF), however their dysregulation in adipose tissues leads to the development of metabolic disorders and obesity (9).