CXCL8 and infection: By necessity, in the setting of multiple chemoattractants, neutrophils must prioritize, favoring end target chemoattractants (e.g., N-Formyl-Met-Leu-Phe, fMLP) emanating from the site of infection over intermediary endogenous chemoattractants [e.g., Leukotriene B4 (LTB4) and interleukin-8 (IL-8)] encountered en route to sites of infection (6).