Gpr41 and Gpr43 KO mice show an impaired immune response when exposed to ethanol-induced gut barrier disruption, 2, 4, 6-trinitrobenzene sulfonic-acid (TNBS)-induced colitis, or oral infection with the mucosal pathogen Citrobacter rodentium, which is characterized by a decreased neutrophil frequency and expression of inflammatory-associated genes (112). Here, FFAR2 is linked to colitis.