Omentin-1 may be a promising treatment for atherosclerosis since exogenous administration of this adipokine prevents atherosclerosis in Apo-e deficient mice by reducing reactive oxygen species synthesis, suppression of TNF-α—induced intracellular adhesion molecule (ICAM) and vascular endothelial cell adhesion molecule (VCAM) expression, and monocyte interaction with vascular endothelium (157). This evidence concerns the gene TNF and atherosclerosis.