Following lncRNA profiling of the isolated cells, we found a signature of differentially expressed lncRNAs and show that specific lncRNAs, Miat (Myocardial infarction associated transcript, also known as Gomafu), and Rian (RNA Imprinted and Accumulated in Nucleus), are part of a rate limiting post-transcriptional network that can potentially be targeted to counteract myofibroblast formation. Here, MEG8 is linked to myocardial infarction.