More recent studies show sortilin involvement in many neurobiological and neuropathological events, such as regulation of neuronal/synaptic viability and activity via its binding and trafficking of neurotrophic factors, mood disorders, dementia and AD-type neuropathology (Hu et al., 2010; Nykjaer and Willnow, 2012; Capsoni et al., 2013; Johnson et al., 2017; Ruan et al., 2018; Xu et al., 2018). Here, SORT1 is linked to Alzheimer disease.