MAPT and frontotemporal dementia: A clear neuropathological hallmark similar to the ALS/FTD spectrum does not exist for schizophrenia; nevertheless, in an autopsy case series on schizophrenic patients, tau-positive glial tangles were found in the dorsal aspect of temporal horn, arcuate fibers in gyri of frontal cortex, and within parahippocampal gyrus, while neurofibrillary tangles were observed in transentorhinal cortex, entorhinal region, subiculum and anterior hippocampus, in almost one third of cases, with increasing prevalence in elderly patients (Casanova et al., 2002).