MAPT and schizophrenia: Though it may not be excluded that aberrancies in tau metabolism are due to neuroleptic drugs (Wisniewski et al., 1994), it is reasonable to hypothesize neurodegenerative processes occur in schizophrenia as well, given the accelerated aging and overall atrophy resulting in severe cognitive decline and motor abnormalities from duration of untreated psychosis (Anderson et al., 2014).