EphA2 is also highly expressed in various types of GBM cell lines, including U87-MG, DBTRG-05M, U251MG, BTCOE 4795, LN229, and T98G (23, 24), as well as in human glioma stem cells (GSC), including D456MG, 827, and 1228 cells. This evidence concerns the gene EPHA2 and central nervous system cancer.