Most of the mutations in EGFR are not functionally validated in oral cancers, and the well-known mutations associated with tyrosine kinase inhibitor (TKI) sensitivity/resistance, such as G719X, T790M, exon 19 deletion/insertion, exon 20 insertions, L858R and L861Q, have not been found in OSCC34,41. Here, EGFR is linked to lip and oral cavity carcinoma.