Interestingly, RIC3 encodes a member of the Resistant to Inhibitor of Cholinesterase 3-like family, which has never been linked to cancer, so the effect of the fusion is actually causing the over-expression of an adjacent gene, LMO1. Since LMO1 gene is aberrantly expressed in a significant fraction of acute lymphoblastic T-cell leukaemia (T-ALL) as a result of chromosomal translocations6,29, it would be reasonable to think that it is this gene and not RIC3 that is truly responsible for tumour development. Here, RIC3 is linked to acute lymphoblastic leukemia.