Since we have detected a significant increase in the expression levels of TAL1 and TP53 in the tumor 521 and NFYC is a direct target of TP53 (https://pathcards.genecards.org/card/direct_p53_effectors), it could be speculated that the chromosomal rearrangements that originates this fusion should operate at the genomic level in such a way that overexpression of TP53 could be responsible for the overexpression of the chimeric transcript. The gene discussed is TAL1; the disease is neoplasm.