RIC3 and cancer: Interestingly, RIC3 encodes a member of the Resistant to Inhibitor of Cholinesterase 3-like family, which has never been linked to cancer, so the effect of the fusion is actually causing the over-expression of an adjacent gene, LMO1. Since LMO1 gene is aberrantly expressed in a significant fraction of acute lymphoblastic T-cell leukaemia (T-ALL) as a result of chromosomal translocations6,29, it would be reasonable to think that it is this gene and not RIC3 that is truly responsible for tumour development.