The canonical NF-κB pathway, triggered by microbial and viral infections, allow to dimers formation containing RelA (also known as p65), c-Rel, or p50 proteins, which are normally retained in the cytoplasm by inhibitors of κB proteins (IκBα, IκBβ, IκBε, IκBγ and Bcl-3). This evidence concerns the gene RELA and viral infectious disease.