TP53 and cancer: Stabilization of p53 with gamma irradiation in normal FTEC, HEK293 cells, or HeyA8 cancer cells did not decrease ACP6 levels but rather led to a modest increase in ACP6 expression, indicating that mutant p53 suppressed ACP6 transcription via gain-of-function activities rather than p53 stabilization (Supplementary Fig. S2i–l).