To determine if the observed effects on focal adhesions were dependent on LPA receptor signaling, we performed a rescue experiment with the LPA receptor antagonist Ki164250: FTEC transiently transfected with siACP6 to mimic the loss of ACP6 in tumor cells that were treated with Ki16425 had reduced paxillin and FAK phosphorylation reversing the effect of ACP6 on focal adhesion signaling (Fig. 3c). Here, PXN is linked to neoplasm.