DA1 treatment significantly reduced the binding of Drp1/ATAD3A in HdhQ111 cells (Fig. 5d and Supplementary Fig. 7A), in striatal cells exposed to 3-NP (Supplementary Fig. 7B) and in striatal extracts of HD R6/2 mice (Fig. 5d), whereas DA2 showed a trend toward inhibition of the interaction (Supplementary Fig. 7A). This evidence concerns the gene DNM1L and Huntington disease.