However, finding a similar protective effect of SIRT1 activation during the early phase of macrophage infection (151) is surprising, given that SIRT1 activation is expected to deacetylate RelA/p65 of NF-κB signaling and diminish the proinflammatory responses of infected macrophages (142, 152), which are required for infection control. Here, SIRT1 is linked to infection.