The islet network identified many “seed” genes with a high T2D PCS (Fig. 4; Additional file 9: Figure S8) as candidate functional genes, including SOX4 ([PCS = 0.62] at the locus usually named for CDKAL1) and ATXN7 ([PCS = 0.57] at the locus named for ADAMTS9). Here, ATXN7 is linked to type 2 diabetes mellitus.