Furthermore, the patterns of enrichment were consistent with underlying physiological expectation: GWAS enrichment for anthropometric and lipid phenotypes was most marked in the APCST networks generated from the insulin-resistant subset of T2D loci (category “insulin response” in [48]), whilst T2D remained the most enriched phenotype for the subsets related to insulin secretion (Fig. 4; Additional file 10: Figure S9). This evidence concerns the gene INS and type 2 diabetes mellitus.