In both the islet-specific (Fig. 4; Additional file 9: Figure S8) and the generic network (Additional file 8: Figure S7), the strongest signals for GWAS enrichment were seen for loci in the three subsets (beta cell [BC] in [48]; acute insulin response [AIR] and peak insulin response in [49]) comprised of T2D GWAS loci which influence T2D risk primarily through a detrimental effect on insulin secretion (Fig. 4; Additional file 9: Figure S8; Additional file 8: Figure S7; Additional file 10: Figure S9). This evidence concerns the gene INS and type 2 diabetes mellitus.