Similarly, additional research to validate emerging immunotherapy targets, such as the protein “V-type immunoglobulin domain-containing suppressor of T-cell activation” (VISTA) [6], also known as V-set immunoregulatory receptor (VSIR), and identify predictive biomarkers should continue for all types of malignant mesothelioma. This evidence concerns the gene VSIR and malignant mesothelioma.