Most patients with SSc have circulating autoantibodies directed against one or more of several SSc autoantigens, including topoisomerase I (Topo1), centromere proteins (Cenp-A and Cenp-B), PM/Scl proteins (PM/Scl-100 and PM-SCl-75), RNA polymerase III (RNAP115 and RNAP11), U1-RNP, fibrillarin, Th/To, NOR90, U11/U12 RNP and Ku [12]. This evidence concerns the gene FBL and systemic sclerosis.