Negative predictors included older age, COPD, advanced NYHA (III+IV), low systolic blood pressure (<110 mmHg), low LVEF (<35%), anaemia, high level of NT-proBNP, hyponatraemia, hyperuricaemia (>500 μmol/l), renal insufficiency (eGFR <60 ml/min) and, in terms of medication, the necessity of taking a higher dose of furosemide (>40 mg daily). The gene discussed is NPPB; the disease is chronic obstructive pulmonary disease.